Late complication of glycogen storage disease type 1b was published on jun 2005 in the journal journal of pediatric endocrinology and metabolism volume 18, issue 6. Recent journal of diabetes and its complications articles. Diabetes mellitus dm is associated with longterm cardiovascular complications, including ischemic heart disease ihd. Diabetes mellitus secondary to pancreatic diseases type 3c, however, is a condition rarely considered in.
Articles on diabetes mellitus open access journals. Diabetes mellitus is a worldwide epidemic affecting the health of. The american diabetes association, jdrf, the european association for the study of diabetes, and the american association of clinical endocrinologists convened a research symposium, the differentiation of diabetes by pathophysiology, natural history and prognosis on 1012 october 2015. Challenge of type 1 diabetes mellitus ilar journal.
Email article thank you for your interest in spreading the word about diabetes. Diabetes mellitus dm was first recognized as a disease around 3000 years ago by the ancient egyptians and indians, illustrating some clinical features very similar to what we now know as diabetes. Diabetes is a growing epidemic in both the developing and developed world and more so in the former. Recent research into the pathophysiology of type 2 dm has led to the introduction of new medications like.
Secondary diabetes mellitus dm has been associated in about 114% of patients with hematologic malignancy treated with lasparaginase. Gestational diabetes mellitus gdm is a form of diabetes that can develop during pregnancy. Risk factors for microvascular atherosclerotic changes in patients with type 2 diabetes mellitus. Many patients with type 2 diabetes mellitus t2dm are on insulin analogues which are. Adrenal insufficiency continues to be a challenge for patients, their physicians, and researchers. These findings might, at least partially, be due to the failure of glucocorticoid replacement therapy to closely resemble physiological. The goal of this study was to determine the effects of diabetes on complications, secondary operations, and functional outcomes after torsional ankle fracture.
Prior to that time, people with type 1 diabetes died without. Even when diabetes is controlled, the disease can lead to chronic renal failure crf. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on healthcare systems. Pathophysiology of diabetes mellitus academic journals. Recent journal of diabetes and its complications articles recently published articles from journal of diabetes and its complications. Canagliflozin and cardiovascular and renal outcomes in. Background type 2 diabetes mellitus t2dm is a global epidemic associated with increased health expenditure, and low quality of life.
Diabetes is known to be associated with hypertension. Diabetes mellitus is a chronic illness with increased morbidity and mortality. In this regard, the study heart rate variability as early biomarker for the evaluation of diabetes mellitus progress by r. Our observation on the prevalence of hypertension and diabetes mellitus is in line with the results of previous studies in china and other countries.
Diabetes mellitus is associated with increased rates of infections. Differentiation of diabetes by pathophysiology, natural. The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulindependent diabetes mellitus. Complications of dm account for increased morbidity, disability, and mortality and represent a threat for the economies of all countries, especially the developing ones. With this background there is a need to study and understand the secondary bacterial infections seen frequently in. The central role of insulin in glucose metabolism regulation was clearly. Recent advances in research into the etiology and natural history of diabetes have increased our knowledge about different types of diabetes to such an extent that primary prevention of diabetes mellitus is becoming a reality. However, data are limited regarding the optimal diet for achieving euglycemia and improved perinatal outcomes. Introduction diabetes mellitus dm is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The primary objective of our study was to determine which factors influence health literacy hl in patients with type 1 diabetes t1d and type 2 diabetes t2d, and the secondary one was to evaluate the infl. The prevention of gestational diabetes mellitus with. Background statins reduce the incidence of cardiovascular events in persons with type 2 diabetes mellitus. The incidence of diabetes mellitus by clinical type was determined for the community of rochester, minnesota, 194569. The study involved a crosssectional analysis of 91 consecutive patients 57 10 yr, 90% men who underwent a cardiopulmonary exercise test at the beginning of an exercisebased standard phaseii cardiac rehabilitation program, 2 to 3 mo after an acute coronary syndrome.
International experts in genetics, immunology, metabolism, endocrinology, and systems biology. Incidence of diabetes mellitus by clinical type diabetes care. Different classes of diabetes mellitus, type 1, type 2, gestational diabetes. Assigning a type of diabetes to an individual often depends on the circumstances present at the time of diagnosis, and many diabetic individuals do not easily fit into a single class. Pathophysiology of type 1 and type 2 diabetes mellitus.
The history of diabetes mellitus pubmed central pmc. Information about the openaccess article a study of secondary bacterial infections in diabetes mellitus in doaj. Pdf resume secondary diabetes mellitus is a recognized complication of organ. It is considered one of the largest emerging threats to health in the 21 st century. Nonetheless, dm may directly impair myocardial and lung structure and function. The central role of insulin in glucose metabolism regulation was clearly demonstrated.
Type 2 diabetes mellitus dm is a major health issue associated with excess mortality and morbidity. The middle east and north africa region has the highest prevalence of diabetes in adults 10. Type 1 diabetes accounts for approximately 10% of all cases of diabetes mellitus and generally afflicts a younger population, with a peak age of around 14 yr. Most downloaded journal of diabetes and its complications articles the most downloaded articles from journal of diabetes and its complications in the last 90 days. Diabetes mellitus dm is a group of metabolic disorders characterised by raised blood sugar due to defects in insulin secretion, action or both. The condition is increasing in epidemic proportions in both developed and developing nations, with the global population predicted to rise from 118 million in 1995 to 220 million in 2010. Paul robertson diabetes has provided scientific information in tences in the recently published history of the american diabetesrelated areas of basic and clinical research diabetes association, the journey and the dream. This monograph provides an overview of the pathophysiology, evaluation, and management of diabetes mellitus and comorbidities in women.
Secondary prevention in diabetes mellitus sciencedirect. It is well known that patients with diabetes mellitus experience higher complication rates after torsional ankle fracture. Type 1 diabetes is the main focus of this journal issue. It is estimated that there will be 380 million persons with dm in 2025.
This translates to a projected rise of diabetes from 171 million in 2000 to well over 350 million in 2030. Research design and methods this was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents gdm. Is cognitive behavioural therapy focusing on depression and. The prevalence of diabetes dm is constantly increasing worldwide at an alarming rate. Journal of diabetes and its complications jdc is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. Dec 20, 2016 checkpoint inhibitor immunotherapy is becoming an effective treatment modality for an increasing number of malignancies. Original article from the new england journal of medicine effects of aspirin for primary prevention in persons with diabetes mellitus. This study aims to investigate whether modified dietary interventions are associated with improved glycemia andor improved birth weight outcomes in women with gdm when compared with. Effects of aspirin for primary prevention in persons with. Changes in mortality rates and ratios in people with pharmacologically treated type 2. Eluting stents or bypass surgery for left main disease. Management of hypertension and diabetes mellitus by. The journal focuses on the primary factors both physical and nervous which work as the major reasons behind this condition to occur. As a result, autoinflammatory sideeffects are also being observed more commonly in the clinic.
This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger. The worldwide prevalence of diabetes in 2000 was approximately 2. Bonus article medical treatment of diabetes mellitus. Topics include etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications such as nephropathy. Table of contents journal of diabetes research hindawi. Diabetes complications severity index dcsiupdate and icd10 translation open access.
Health literacy and glycemic control in patients with diabetes. Objective this study investigated if inositol in a combination of myo inositol and d chiroinositol would prevent gestational diabetes mellitus gdm in women with a family history of diabetes. International journal of diabetes and clinical research clinmed. Diabetes mellitus dm is a clinical syndrome associated with deficiency of insulin secretion or action. The journal has blood sugar level charts to determine the correct level. Comparison of the effects of gemigliptin and dapagliflozin on glycaemic variability in type 2 diabetes. Effectiveness of ipragliflozin, a sodiumglucose cotransporter 2 inhibitor, as a secondline treatment for nonalcoholic fatty liver disease patients with type 2 diabetes mellitus who do not respond to incretinbased therapies including glucagonlike peptide1 analogs and dipeptidyl peptidase4 inhibitors. Atorvastatin in patients with type 2 diabetes mellitus.
Prevalence, awareness, treatment, control of type 2 diabetes. Diagnosis and management of adrenal insufficiency the. Njagi3 1department of biochemistry and biotechnology, kenyatta university, p. According to the international diabetes federation in 2015, an estimated 415 million people globally were suffering from this condition. The molecular genetics of diabetes received extensive attention in recent years by many prominent investigators and research groups in the biomedical field. Publication trends of research on diabetes mellitus and t cells plos. Home journal of the american heart association vol. It places an enormous burden on already sparse resources. During the past decade, longterm studies have shown increased mortality and morbidity and impaired quality of life in patients with adrenal insufficiency. Incidence of diabetes mellitus by clinical type diabetes. Effects of diabetes mellitus on functional outcomes and. Pdf chronic renal failure secondary to diabetes mellitus. Overall adjusted incidence rates per 100,000 personyears were 8. Aetiology and pathology of type 2 diabetes mellitus.
Prevention of the two major forms of diabetes, iddm and niddm, are quite separate issues. The diabetes control and complications trial research group. The diabetes control and complications trial research group the effect of intensive treatment of diabetes on the development and progression of longterm complications in insulindependent diabetes mellitus. Journal of diabetes and its complications elsevier. Chronic, heavy alcohol consumption, an independent risk factor for type 2 diabetes mellitus t2dm, disrupts the glucose homeostasis and is associated with development of insulin resistance. Diabetes can also result from another disease, such as a ncr e t is,ov f m dlu g pancreatectomy surgical rem ov al f th p nc s or cer tain medications. The prevalence of diabetes mellitus is increasing among women of all ages. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.
Articles on diabetes mellitus diabetes mellitus also known as simply diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Objective medical nutrition therapy is a mainstay of gestational diabetes mellitus gdm treatment. Pancreatogenic diabetes is a form of secondary diabetes, classified by the american diabetes association ada and the world health organization as type 3c diabetes mellitus t3cdm. Type 2 diabetes used to be called adultonset diabetes and noninsulindependent diabetes mellitus niddm. Diabetes mellitus is a complex metabolic disorder associated with an increased risk of microvascular and macrovascular disease. Pittsburgh diabetes mellitus study american journal of. Jun 25, 2015 different classes of diabetes mellitus, type 1, type 2, gestational diabetes and other types of diabetes mellitus are compared in terms of diagnostic criteria, etiology and genetics. They also demonstrated correlation between type 2 diabetes mellitus and cortical lens opacities.
Diabetes mellitus a devastating metabolic disorder. The list below are some of the top features of this journal of diabetes. The chronic hyperglycaemia of dm is associated with longterm damage, dysfunction and. Find, read and cite all the research you need on researchgate. The presence of both hypertension and diabetes mellitus ranged from 17. Screening and diagnosis is still based on world health organization who and american diabetes association ada criteria which include both clinical and laboratory parameters. Jdm is an international journal dedicated to the current developments of diabetes mellitus, the broad scope will also include significant research in the fields of pathology. Proximal myopathy, secondary hypertension and diabetes mellitus were all. Recently published articles from diabetes research and clinical practice. To emphasize the impact of diabetes on the renal parenchyma at much earlier stages of the disease, the national kidney foundations kidney dialysis outcomes quality initiative clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease now promote the term diabetic kidney disease dkd as a. A further aspect that should be investigated is the genetic predisposition for an increased risk of sarscov2 infection, which might be due to ace2 polymorphisms that have been linked to diabetes mellitus, cerebral stroke, and hypertension, specifically in.
The impact of diabetes mellitus open access article pdf epub. The last century has been characterised by remarkable advances in our understanding of the mechanisms leading to hyperglycaemia. We are currently unable to predict which patients will develop more severe toxicities associated with these treatment regimens. Most downloaded journal of diabetes and its complications. Journal of diabetes research table of contents journal of diabetes research publishes articles related to type 1 and type 2 diabetes. You can determine the level between low, medium, and high ranges. The book contains 80 pages filled with the important information on sugar levels. Evans jm, newton rw, ruta da, macdonald tm, stevenson rj, morris ad. An 11year old filipino female, diagnosed with acute lymphoblastic leukemia, developed hyperglycemia associated with polyuria and polydipsia while ongoing induction chemotherapy. Diabetes mellitus a devastating metabolic disorder 1, g. Perspectives in diabetes history of diabetes, the journal 1. Secondary prevention of cardiovascular disease in patients. Genetic risk analysis of a patient with fulminant autoimmune.
Commercially produced insulin was not available in the united states until 1923 when shortacting regular insulin required multiple injections a day white, 2014. A study of secondary bacterial infections in diabetes. Aug 11, 2016 the study aimed to investigate prevalence, awareness, treatment and control of type 2 diabetes mellitus t2dm, and to explore potential risk factors in rural areas of china. Is cognitive behavioural therapy focusing on depression and anxiety effective for people with longterm physical health conditions. High serum glucose levels aid the colonization and also growth of a variety of organisms.
Primary prevention of both insulindependent diabetes mellitus iddm and niddm has become increasingly important because of their significant morbidity and mortality and the human and economic costs associated with diabetes and its complications. Journal of diabetes mellitus rg journal impact rankings. The aim of this study was to assess the impact of type 2 dm t2dm and glycemic control on cardiopulmonary exercise capacity in patients with ihd. Antithrombotic therapy for secondary prevention in. Research has also suggested that a lowcarbohydrate ketogenic diet. Citescore values are based on citation counts in a given year e. Saxena et al 17 found a 2fold higher incidence of cortical cataracts in subjects with diabetes mellitus over 5 years. Transient diabetes mellitus secondary to lasparaginase. Many nongenetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed. Learn the benefits of becoming an ahaasa professional member and join. Primary prevention of diabetes mellitus diabetes care. Prevalence of maturityonset diabetes of the young mody is estimated between 1 and 2% of all diabetes cases. Perspectives in diabetes history of diabetes, the journal 1 9521 991 editors swan song r. Recent diabetes research and clinical practice articles elsevier.
Mlr1023 clinicalproofofconcept in type 2 diabetes mellitus. O box 4384400100, nairobi 2department of pure and applied sciences, technical university of mombasa, p. Pdf secondary diabetes mellitus in patients with endogenous. Diabetes mellitus, pathophysiology, pathogenesis, etiology. Diabetes, gum disease, and other dental problems national institute of diabetes and digestive and kidney diseases also in spanish. Type 2 diabetes mellitus, glycated hemoglobin levels, and. Definitely, more extensive research is needed in this field that will. Mar 11, 2020 atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes. Methods we searched pubmed to capture all metaanalyses and mendelian randomization studies for risk factors of t2dm.
Until now, few studies have attempted to test measures for primary prevention of diabetes. A controlled trial in the context of type 2 diabetes mellitus volume 46 issue 2 abigail l. However, the benefit of statins in such patients receiving hemodialysis, who are at high r. The presence of one increases the risk of having the other. Jdc also publishes articles on physiological and molecular aspects of glucose homeostasis. Are patients with hypertension and diabetes mellitus at. Pathophysiology of diabetes mellitus the journal supports. In addition, there are uncommon inherited disorders that cause diabetes, such as maturityonset diabetes of the young and wolfram syndrome. Patients with type 2 diabetes mellitus and chronic kidney disease are at increased risk of cardiovascular events. Introduction diabetes mellitus dm is the most common cause of renal failure.